Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2N653)

Drug Name

example 98 (WO2011020806) Drug Info

Synonyms

GTPL6540; SCHEMBL1173236; example 98 [WO2011020806]

Indication

Disease Entry	ICD 11	Status	REF
Focal segmental glomerulosclerosis	MF8Y	Clinical trial	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Beta-site APP-cleaving enzyme 2 (BACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID21907142CJ	DMST0IN	Discovery agent	N.A.	Investigative	[3]
example 2 (WO2013004676)	DMU25HZ	Discovery agent	N.A.	Investigative	[4]
example 20 (WO2010128058)	DMF9W41	Discovery agent	N.A.	Investigative	[5]
example 41 (WO2012028563)	DM2N9Y8	Discovery agent	N.A.	Investigative	[5]
2ewy	DMNOAJG	Discovery agent	N.A.	Investigative	[6]
example 92 (WO2012095521)	DMU42CR	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Beta-site APP-cleaving enzyme 2 (BACE2)	TT69DB8	BACE2_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6540).
2	BACE2 as a new diabetes target: a patent review (2010 - 2012). Expert Opin Ther Pat. 2013 May;23(5):649-63.
3	Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab. 2011 Sep 7;14(3):365-77.
4	Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors. ACS Med Chem Lett. 2013 Mar 15;4(4):379-80.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2331).
6	Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. J Mol Biol. 2006 Jan 13;355(2):249-61.