Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2OB6S)

Drug Name

CI-8993 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting V-set immunoregulatory receptor (VSIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CA-170	DMOUHR4	Lymphoma	2A80-2A86	Phase 1	[3]
JNJ-61610588	DMSPQDM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
V-set immunoregulatory receptor (VSIR)	TT51SK8	VISTA_HUMAN	Antagonist	[2]

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References

1	ClinicalTrials.gov (NCT04475523) Phase 1 Study of CI-8993 Anti-VISTA Antibody in Patients With Advanced Solid Tumor Malignancies. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Curis.
3	Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)