Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2V4MJ)

Drug Name

PMID24900699C68 Drug Info

Synonyms

GTPL8165; BDBM50434356

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

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Drug(s) Targeting Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID28766366-Compound-Scheme21Left	DMWTRUK	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme21Right	DMF3X40	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme14BINDY	DMBQ0RN	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme2WO2012/098065bottom	DMO4Q95	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme7WO2012/098070upper	DMGAQR5	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme9EHT1610	DMMZGC8	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme9EHT5372	DM0O18N	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme25-2	DM7OGWH	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme2WO2012/098065upper	DMVJDRI	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme7WO2012/098070bottom	DMQV6R0	N. A.	N. A.	Patented	[3]
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Drug(s) Targeting Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Harmine	DMPA5WD	Discovery agent	N.A.	Patented	[3]
PMID28766366-Compound-Scheme21Left	DMWTRUK	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme21Right	DMF3X40	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme14BINDY	DMBQ0RN	N. A.	N. A.	Patented	[3]
TG003	DMP4HR2	Discovery agent	N.A.	Patented	[3]
PMID28766366-Compound-Scheme2WO2012/098065bottom	DMO4Q95	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme16DMAT	DMQ5UEA	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme7WO2012/098070upper	DMGAQR5	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme9EHT1610	DMMZGC8	N. A.	N. A.	Patented	[3]
PMID28766366-Compound-Scheme9EHT5372	DM0O18N	N. A.	N. A.	Patented	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)	TTSBVFO	DYR1A_HUMAN	Inhibitor	[2]
Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)	TTYGQ8A	DYR1B_HUMAN	Inhibitor	[2]

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References

1	Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Neurobiol Dis. 2005 Nov;20(2):392-400.
2	Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down's Syndrome or Alzheimer's Disease. ACS Med Chem Lett. 2013 Apr 26;4(6):502-3.
3	Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199.