Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM31OGZ)

Drug Name

MONTIRELIN TETRAHYDRATE Drug Info

Synonyms

NS-3; Montirelin tetrahydrate; Remnos (Nippon Shinyaku, JP); (2R,5R)-N-(2-Methyl-3-oxothiomorpholin-5-ylcarbonyl)-L-histidyl-L-prolinamide tetrahydrate

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Discontinued in Preregistration	[1]

Cross-matching ID

PubChem CID: 53297483
TTD Drug ID: DM31OGZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Thyrotropin-releasing hormone receptor (TRHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
protirelin	DMGN5QD	Central nervous system disease	8A04-8D87	Approved	[3]
AZETIRELIN	DMLY9F1	Pain	MG30-MG3Z	Phase 3	[4]
Posatirelin	DML6EWH	Neurodegenerative disorder	8A20-8A23	Discontinued in Phase 3	[5]
JTP-2942	DM29C6S	Cognitive impairment	6D71	Discontinued in Phase 2	[6]
MK-771	DM4YQV0	Discovery agent	N.A.	Investigative	[7]
CORYMBONE B	DM463S2	Discovery agent	N.A.	Investigative	[8]
C4X-101	DM5971G	Endocrine disease	5B3Z	Investigative	[9]
MeTRH	DMGH8WV	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thyrotropin-releasing hormone receptor (TRHR)	TT4J8MF	TRFR_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001824)
2	Montirelin hydrate (NS-3), a TRH analog, improved the disturbance of consciousness caused by head concussion and pentobarbital in mice. Nihon Yakurigaku Zasshi. 1996 May;107(5):237-45.
3	Company report (takeda)
4	Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. II. In situ and in vitro absorption characteristics of azetirelin from the rat intestine. Biol Pharm Bull. 1995 Jul;18(7):976-9.
5	TRH analogs at Gedeon Richter Ltd.: highlights of experimental and clinical efficacy of posatirelin. Acta Pharm Hung. 2002;72(1):62-8.
6	Effect of JTP-2942, a novel thyrotropin-releasing hormone analogue, on pentobarbital-induced anesthesia in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):177-82.
7	TRH analog MK-771 reverses neurochemical and learning deficits in medial septal-lesioned rats. Peptides. 1989 Jan-Feb;10(1):121-4.
8	Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata. J Nat Prod. 2008 May;71(5):881-3.
9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 363).
10	Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice. Neuropsychopharmacology. 2013 May;38(6):950-6.