Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3DQXG)

Drug Name

NPSP-795 Drug Info

Synonyms

NPSP-790; SB-423557; SB-423557A; SB-423562; SB-423562A

Indication

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Parathyroid hormone receptor (PTH2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BA-058	DMPV6B2	Osteoporosis	FB83.0	Phase 3	[3]
GSK768974	DMIEXUM	Osteoporosis	FB83.0	Phase 2	[4]
UNI-PH (1-34)	DM8LBUK	Osteoporosis	FB83.0	Phase 2	[5]
PTH(7-34) liposomal cream	DMRQ5YT	Alopecia	ED70	Phase 1	[6]
Semparatide	DMLK605	Osteoporosis	FB83.0	Discontinued in Phase 2	[7]
BB-PTH 1-84	DM85AJ4	Osteoporosis	FB83.0	Investigative	[2]
PTHr pepducins	DM10KIW	Endocrine disease	5B3Z	Investigative	[2]
Hemoparatide	DMF7X31	Discovery agent	N.A.	Investigative	[8]
ZP-2307	DM8WRAU	Osteoporosis	FB83.0	Investigative	[2]
SDZ-PTS-893	DMBYSEM	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Parathyroid hormone receptor (PTH2R)	TTEPJL5	PTH2R_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT02204579) A Study to Determine the Effects of NPSP795 on the Calcium-sensing Receptor in Subjects With Autosomal Dominant Hypocalcemia as Measured by PTH Levels and Blood Calcium Concentrations. U.S. National Institutes of Health.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 332).
3	Emerging therapies for the treatment of osteoporosis. J Midlife Health. 2013 Jul-Sep; 4(3): 147-152.
4	Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice. Bone. 2000 Oct;27(4):471-8.
5	Parathyroid hormone for the treatment of osteoporosis: a systematic review. CMAJ. 2006 July 4; 175(1): 52-59.
6	Differential effects of intermittent PTH(1-34) and PTH(7-34) on bone microarchitecture and aortic calcification in experimental renal failure. Bone. 2008 Dec;43(6):1022-30.
7	Quantitative cell membrane-based radioligand binding assays for parathyroid hormone receptors. J Pharmacol Toxicol Methods. 1999 Apr-Jun;41(2-3):83-90.
8	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
9	Long-term therapy of ovariectomy-induced osteopenia with parathyroid hormone analog SDZ PTS 893 and bone maintenance in retired breeder rats. Bone. 1999 Nov;25(5):561-9.