Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3ED1A)

Drug Name
Tavaborole Drug Info
Synonyms
Kerydin; AN2690; AN-2690; AN-2690); SCH-900340; Topical antifungal (onychomycosis), Merck & Co; Trichophyton-targeting antifungal (onychomycosis), Merck & Co; Fungal leucyl-tRNA synthetase inhibitor (onychomycosis), Anacor Pharmaceuticals/Schering-Plough; Fungal leucyl-tRNA synthetase inhibitor (onychomycosis), Merck & Co/Anacor; Trichophyton-targeting antifungal (onychomycosis), Anacor Pharmaceuticals/Schering-Plough
Indication
Disease Entry ICD 11 Status REF
Onychomycosis EE12.1 Approved [1]
Cross-matching ID
PubChem CID
11499245
ChEBI ID
CHEBI:77942
CAS Number
CAS 174671-46-6
TTD Drug ID
DM3ED1A
ACDINA Drug ID
D01462

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Staphylococcus Leucyl-tRNA synthetase (Stap-coc leuS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GSK-2251052 DMLFI7Q Urinary tract infection GC08 Phase 2 [3]
AN-2718 DM8B2WQ Fungal infection 1F29-1F2F Phase 1 [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Staphylococcus Leucyl-tRNA synthetase (Stap-coc leuS) TT37GL6 SYL_STAAE Inhibitor [2]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science. 2007 Jun 22;316(5832):1759-61.
3 Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.
4 Metalloid compounds as drugs. Res Pharm Sci. 2013 Jul-Sep; 8(3): 145-158.