Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3HR7F)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Approved Drug(s)

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Drug(s) Targeting Cysteines of Keap1 (KEAP1 Cysteines)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CXA10	DMM7Z6K	Focal segmental glomerulosclerosis	MF8Y	Phase 2	[2]
PMID28454500-Compound-8	DM6BQFA	N. A.	N. A.	Patented	[1]
Pyrazino[2,1-a]isoquinolin derivative 4	DMKTNBC	N. A.	N. A.	Patented	[1]
PMID28454500-Compound-36	DM5RZWG	N. A.	N. A.	Patented	[1]
Chalcone derivative 4	DM45COR	N. A.	N. A.	Patented	[1]
2-hydroxybenzamide derivative 1	DMER2ZQ	N. A.	N. A.	Patented	[1]
Vinyl sulfone derivative 1	DMTMFNK	N. A.	N. A.	Patented	[1]
Pyrazino[2,1-a]isoquinolin derivative 2	DMYXKQ3	N. A.	N. A.	Patented	[1]
Diterpenoid derivative 1	DMAZOH4	N. A.	N. A.	Patented	[1]
PMID28454500-Compound-13	DM7SIVA	N. A.	N. A.	Patented	[1]
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Drug(s) Targeting Nuclear factor erythroid 2-related factor 2 (Nrf2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Omaveloxolone	DMLMNFX	Friedreich's ataxia	8A03.10	Approved	[3]
CXA10	DMM7Z6K	Focal segmental glomerulosclerosis	MF8Y	Phase 2	[2]
SFX-01	DMAQW9M	Breast cancer	2C60-2C65	Phase 2	[4]
ABT-RTA-408	DM9Y1XB	Non-small-cell lung cancer	2C25.Y	Phase 2	[5]
OT-551	DMTNOXQ	Ocular inflammation	9C61.24	Phase 2	[6]
OT551	DMHKIOF	Age-related macular degeneration	9B75.0	Phase 2	[7]
HPP971	DMZXG7Q	Non-alcoholic steatohepatitis	DB92.1	Phase 1	[8]
PMID28454500-Compound-57	DMTK9M6	N. A.	N. A.	Patented	[1]
PMID28454500-Compound-8	DM6BQFA	N. A.	N. A.	Patented	[1]
Pyrazino[2,1-a]isoquinolin derivative 4	DMKTNBC	N. A.	N. A.	Patented	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cysteines of Keap1 (KEAP1 Cysteines)	TT3Z6Y9	KEAP1_HUMAN	Modulator	[1]
Nuclear factor erythroid 2-related factor 2 (Nrf2)	TTA6ZN2	NF2L2_HUMAN	Activator	[1]

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References

1	Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785.
2	The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophys Rev. 2017 Feb;9(1):41-56.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov. 2019 Apr;18(4):295-317.
5	National Cancer Institute Drug Dictionary (drug id 756624).
6	New hope for dry AMD. Nat Rev Drug Discov. 2013 Jul;12(7):501-2.
7	Nitroxide pharmaceutical development for age-related degeneration and disease. Front Genet. 2015 Nov 6;6:325.
8	Clinical pipeline report, company report or official report of vTv Therapeutics.