General Information of Drug (ID: DM3KARJ)

Drug Name
GSK2647544 Drug Info
Synonyms GSK-2647544
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 1 [1]
Cross-matching ID
PubChem CID
57336782
TTD Drug ID
DM3KARJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rilapladib DMB9861 Arteriosclerosis BD40 Phase 1 [3]
Indolizine derivative 1 DM4GZBI N. A. N. A. Patented [4]
Bicyclic pyrimidine derivative 2 DMJP16K N. A. N. A. Patented [4]
RPAF-AH DMOVJ60 Sepsis 1G40-1G41 Discontinued in Phase 3 [5]
GSK568859 DM6E84O Arteriosclerosis BD40 Discontinued in Phase 1 [2]
Goxalapladib DMSGUY9 Arteriosclerosis BD40 Discontinued in Phase 1 [6]
(1r)-1,2,2-trimethylpropyl (r)-methylphosphinate DMVE34H Discovery agent N.A. Investigative [7]
Benzaldehyde O-benzoyloxime DMB7DFT Discovery agent N.A. Investigative [8]
(E)-(thiophen-2-ylmethylidene)amino benzoate DMHSJAT Discovery agent N.A. Investigative [9]
3,4-difluorobenzaldehyde O-benzoyloxime DMFV3Y9 Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Platelet-activating factor acetylhydrolase (PLA2G7) TTDNFMT PAFA_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT01924858) A Positron Emission Tomography (PET) Study to Investigate the Brain Biodistribution of 18F GSK2647544 in Healthy Subjects to Determine Its Ability to Cross the Blood-brain-barrier.. U.S. National Institutes of Health.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1432).
3 Phospholipase A2 inhibitors. Curr Opin Lipidol. 2009 Aug;20(4):327-32.
4 Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006777)
6 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020582)
7 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
8 Potent inhibitors of lipoprotein-associated phospholipase A(2): benzaldehyde O-heterocycle-4-carbonyloxime. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5576-9.
9 (E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1525-7.