Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3L2GT)

Drug Name

O6-Benzylguanine alkylade Drug Info

Synonyms

KRX-0402; O6-Benzylguanine (BG)

Indication

Disease Entry	ICD 11	Status	REF
Sarcoma	2A60-2C35	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting O-6-methylguanine-DNA-alkyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
6-Benzyloxy-9H-purin-2-ylamine	DMFI7A8	Discovery agent	N.A.	Investigative	[2]
S-Methylcysteine	DMAMRKS	Discovery agent	N.A.	Investigative	[3]
6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine	DMUFSE2	Discovery agent	N.A.	Investigative	[2]
6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine	DMK8XIO	Discovery agent	N.A.	Investigative	[2]
Benzylcysteine	DMTCYHM	Discovery agent	N.A.	Investigative	[3]
6-Allyloxy-9H-purin-2-ylamine	DMI2XUQ	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
O-6-methylguanine-DNA-alkyltransferase (MGMT)	TTJ8DV7	MGMT_HUMAN	Modulator	[1]

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References

1	Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10;27(8):1262-7.
2	Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-... J Med Chem. 1998 Feb 12;41(4):503-8.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)gua... J Med Chem. 2000 Nov 2;43(22):4071-83.