Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3MH2H)

Drug Name

ALMB-0166 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Spinal cord injury	ND51.2	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Granexin gel	DMZS2R7	Diabetic foot ulcer	BD54	Phase 3	[3]
Act1	DMXYRPO	Wound healing	EL8Y	Phase 3	[4]
HCB1019	DMX8C6J	Diabetic macular edema	9B71.02	Phase 2	[5]
ALMB-0168	DMB0LSF	Osteosarcoma	2B51	Phase 1/2	[6]
octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gap junction alpha-1 protein (GJA1)	TT4F7SL	CXA1_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT05524103) A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ALMB-0166 in Patients With Acute Spinal Cord Injury. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of AlaMab Therapeutics
3	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
4	Company report (FirstString Research)
5	Clinical pipeline report, company report or official report of OcuNexus Therapeutics.
6	Clinical pipeline report, company report or official report of AlaMab Therapeutics
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 728).