General Information of Drug (ID: DM3NQDW)

Drug Name
NSC-125034 Drug Info
Synonyms
NSC125034; NSC-125034; CHEMBL239439; 8-Quinolinol, 2,2'-dithiobis-; AC1L5KEF; NCIStruc1_001467; NCIStruc2_001671; SCHEMBL2534563; CTK8A0185; 2,2'-disulfanediyldiquinolin-8-ol; NCI125034; BDBM50198307; ZINC37868596; NCGC00014270; CCG-37229; NCGC00097379-01; NCGC00014270-02; NCI60_000583; 2-(8-hydroxyquinolin-2-yl)disulfanylquinolin-8-ol; 2-[(8-hydroxy-2-quinolyl)disulfanyl]quinolin-8-ol; 2-[(8-hydroxyquinolin-2-yl)disulfanyl]quinolin-8-ol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
276707
TTD Drug ID
DM3NQDW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NSC-661755 DMDJT7U N. A. N. A. Terminated [1]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [2]
MANGOSTIN DMYQGDV Discovery agent N.A. Investigative [1]
PUUPEHENONE DMF3BCK Discovery agent N.A. Investigative [3]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [2]
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol DMLDQWT Discovery agent N.A. Investigative [3]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol DMO34LJ Discovery agent N.A. Investigative [4]
NSC-292213 DMNUSKT Discovery agent N.A. Investigative [1]
Jaspic acid DMOF0TB Discovery agent N.A. Investigative [3]
DYSIDENIN DMIZQTX Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 12-lipoxygenase (12-LOX) TT12ABZ LOX12_HUMAN Inhibitor [1]

References

1 Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
2 Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.
3 Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5.
4 Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.