Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3YO72)

Drug Name

3-hydroxy-3-methyl-6-phosphohexanoic acid Drug Info

Synonyms

3-hydroxy-3-methyl-6-phosphonohexanoic acid; 63370-13-8; GTPL3202; SCHEMBL11310701; CTK2A9401; DTXSID80634286; Hexanoic acid, 3-hydroxy-3-methyl-6-phosphono-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 23452327
CAS Number: CAS 63370-13-8
TTD Drug ID: DM3YO72

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Phosphomevalonate kinase (PMVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(R)-5-diphosphomevalonate	DMOESL1	Discovery agent	N.A.	Investigative	[3]
cinnamic acid	DM340FH	Discovery agent	N.A.	Investigative	[4]
isoferulic acid	DMN23KT	Discovery agent	N.A.	Investigative	[4]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphomevalonate kinase (PMVK)	TTXMI0C	PMVK_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3202).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 641).
3	Functional evaluation of conserved basic residues in human phosphomevalonate kinase. Biochemistry. 2007 Oct 23;46(42):11780-8.
4	Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. Biochem J. 1979 Jul 1;181(1):143-51.