Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3Z6F4)

Drug Name

PMID23147077C10 Drug Info

Synonyms

GTPL8133; BDBM50334268; ZINC43193842; MRF-0000031; NCGC00344859-04

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Apoptosis signal-regulating kinase 1 (MAP3K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GS-4977	DMBDFN7	Diabetic nephropathy	GB61.Z	Phase 2	[2]
GS-4997	DMNABMU	Diabetic nephropathy	GB61.Z	Phase 2	[2]
MSC2032964A	DMS3O9H	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis signal-regulating kinase 1 (MAP3K5)	TTOQCD8	M3K5_HUMAN	Inhibitor	[1]
Apoptosis signal-regulating kinase 2 (MAP3K6)	TT64GC2	M3K6_HUMAN	Inhibitor	[1]

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References

1	Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9.
2	Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33.
3	Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med. 2010 Dec;2(12):504-15.