Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM40ORU)

Drug Name

BAY-44-3428 Drug Info

Synonyms

APC-1167

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Tryptase alpha/beta-1 (Tryptase)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[3]
Lactoferrin	DMA7QTC	Solid tumour/cancer	2A00-2F9Z	Approved	[3]
APC-2059	DM8IB6K	Inflammatory bowel disease	DD72	Discontinued in Phase 2	[4]
APC-366	DM02DNQ	Asthma	CA23	Discontinued in Phase 2	[3]
BABIM	DM8AGOE	Asthma	CA23	Terminated	[3]
BAY-17-1998	DM7LZFQ	Asthma	CA23	Terminated	[5]
Grassystatin a	DM1PWX2	Discovery agent	N.A.	Investigative	[6]
BMS-262084	DMETNA3	Discovery agent	N.A.	Investigative	[7]
AMG-126737	DM9H7AZ	Discovery agent	N.A.	Investigative	[8]
MOL 6131	DMSF8UC	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tryptase alpha/beta-1 (Tryptase)	TTM1TDX	TRYB1_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010843)
2	Bayer AG to Develop Arris Asthma Compound; Arris to Receive Milestone Payment. 1996 Business Wire
3	Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96.
4	Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002 Mar;16(3):407-13.
5	Bayer AG to Develop Arris Asthma Compound; Arris to Receive Milestone Payment. 1996 Business Wire
6	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
7	Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3229-33.
8	Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol. 2002 Feb 15;168(4):1992-2000.