Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM450XS)

Drug Name

BAY 2253651 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Obstructive sleep apnea	7A41	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting TWIK-related acid-sensitive potassium channel 1 (TASK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY-2253651	DMM7Q68	Obstructive sleep apnea	7A41	Phase 2	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TWIK-related acid-sensitive potassium channel 1 (TASK1)	TTGR91N	KCNK3_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT03603678) Obstructive Sleep Apnea (OSA) Treated With a Potassium Channel Inhibitor (SANDMAN). U.S. National Institutes of Health.
2	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.