Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM48HVI)

Drug Name

JTT-551 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Type-2 diabetes	5A11	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Protein-tyrosine phosphatase 1B (PTP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IONIS-PTP1BRX	DMGTJUP	Type-2 diabetes	5A11	Phase 2	[2]
TTP-814	DMH9RGV	Diabetic complication	5A2Y	Phase 1/2	[3]
Trodusquemine	DMQ7UN6	Breast cancer	2C60-2C65	Phase 1	[4]
KQ-791	DMK0BTN	Type-2 diabetes	5A11	Phase 1	[2]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein-tyrosine phosphatase 1B (PTP1B)	TTMS7KP	PTN1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice. J Diabetes Res. 2014;2014:680348.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Protein tyrosine phosphatase 1B (PTP-1B; PTPN1). SciBX 5(7); doi:10.1038/scibx.2012.176. Feb. 16 2012
4	Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-23.