Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM493GU)

Drug Name

5-oxo-20-HETE Drug Info

Synonyms

5-oxo-20-hydroxy-6E, 8Z,11Z, 14Z-eicosatetraenoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Oxoeicosanoid receptor 1 (OXER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
5S-HETE	DM3Z6G4	Discovery agent	N.A.	Investigative	[3]
5S-HPETE	DME1304	Discovery agent	N.A.	Investigative	[3]
5-oxo-C20:3	DM6FSUW	Discovery agent	N.A.	Investigative	[4]
5-(6-chloro-2-hexyl-1H-indol-1-yl)-5-oxo-valeric acid	DM0K7U5	Discovery agent	N.A.	Investigative	[5]
5-oxo-12-HETE	DMLABR9	Discovery agent	N.A.	Investigative	[6]
5-oxo-15-HETE	DM9ZC7B	Discovery agent	N.A.	Investigative	[2]
Gue1654	DM89KNT	Discovery agent	N.A.	Investigative	[7]
[3H]5-oxo-ETE	DM50WFM	Discovery agent	N.A.	Investigative	[8]
5-oxo-ODE	DM56TVA	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxoeicosanoid receptor 1 (OXER1)	TT7WBSV	OXER1_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6169).
2	Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils. J Immunol. 1996 Jan 1;156(1):336-42.
3	TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis. Biochem Biophys Res Commun. 2005 Sep 9;334(4):987-95.
4	Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity. J Pharmacol Exp Ther. 2008 May;325(2):698-707.
5	5-Oxo-ETE receptor antagonists. J Med Chem. 2013 May 9;56(9):3725-32.
6	Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets. Blood. 1999 Feb 1;93(3):1086-96.
7	A biased ligand for OXE-R uncouples Galpha and Gbetagamma signaling within a heterotrimer. Nat Chem Biol. 2012 Jul;8(7):631-8.
8	Receptors for the 5-oxo class of eicosanoids in neutrophils. J Biol Chem. 1998 Dec 4;273(49):32535-41.
9	Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant. J Biol Chem. 2008 Apr 25;283(17):11234-43.