Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4953W)

• Drug Name: KOS-2187 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Gastroesophageal reflux disease	DA22.Z	Phase 1	[1]
Gastrointestinal disease	DE2Z	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 56603679
  TTD Drug ID: DM4953W

Molecule-Related Drug Atlas

Drug(s) Targeting Motilin receptor (MLNR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MOTILIN	DMVILAD	N. A.	N. A.	Phase 4	[3]
Camicinal	DMAKSMX	Delayed gastric emptying	DA41.00	Phase 2	[4]
Mitemcinal fumarate	DMOJ7QA	Pain	MG30-MG3Z	Phase 2	[5]
RWJ-68023	DM4O07Q	Irritable bowel syndrome	DD91.0	Phase 1	[6]
DS-3801	DM6WN9X	Constipation	DD91.1	Phase 1	[7]
GSK-1322888	DMNYGB8	Gastroparesis	DA41.00	Phase 1	[8]
KW-5139	DMLOKXI	Pain	MG30-MG3Z	Discontinued in Phase 2	[9]
KC-11458	DMOITN2	Gastric motility disorder	DA21	Discontinued in Phase 2	[10]
SLV-305	DMBZM0D	Gastric motility disorder	DA21	Discontinued in Phase 2	[4]
SLV-311	DM5TJIY	Gastrointestinal disease	DE2Z	Discontinued in Phase 1	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Motilin receptor (MLNR)	TT953CX	MTLR_HUMAN	Agonist	[2]

References

• [1] Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26.
• [2] Kosan Announces Selection of KOS-2187 As Motilide Clinical Candidate at World Congress of Gastroenterology Meeting. Kosan. 2006.
• [3] Discovery of a new class of macrocyclic antagonists to the human motilin receptor. J Med Chem. 2006 Nov 30;49(24):7190-7.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297).
• [5] Clinical pipeline report, company report or official report of Roche (2009).
• [6] Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function. Br J Clin Pharmacol. 2004 Apr;57(4):393-401.
• [7] Clinical pipeline report, company report or official report of Daiichi Sankyo.
• [8] ClinicalTrials.gov (NCT01294566) FTIH to Evaluate Safety, Tolerability, and Pharmacokinetics of Single Oral Doses of GSK1322888 in Healthy Caucasian and Japanese Volunteers. U.S. National Institutes of Health.
• [9] Stimulating action of KW-5139 (Leu13-motilin) on gastrointestinal motility in the rabbit. Br J Pharmacol. 1994 Jan;111(1):288-94.
• [10] Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis. Aliment Pharmacol Ther. 2004 Aug 1;20(3):333-8.
• [11] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017412)