Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4CY2G)

Drug Name

PEDF gene therapy Drug Info

Synonyms

AdPEDF; AdGVPEDF.11D; PEDF gene therapy (ophthalmic); PEDF gene therapy (ophthalmic), GenVec; Pigment epithelium-derived factor gene therapy, GenVec

Indication

Disease Entry	ICD 11	Status	REF
Macular degeneration	9B78.3	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Pigment epithelium-derived factor (SERPINF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AdPEDR	DME384W	Exudative age-related macular degeneration	9B78.3Z	Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pigment epithelium-derived factor (SERPINF1)	TTR59S1	PEDF_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT00109499) Study of AdGVPEDF.11D in Neovascular Age-related Macular Degeneration (AMD). U.S. National Institutes of Health.
2	Adenovector pigment epithelium-derived factor (AdPEDF) delivery for wet age-related macular degeneration. Retina. 2005 Dec;25(8 Suppl):S48-S49.
3	Future pharmacological treatment options for nonexudative and exudative age-related macular degeneration. Expert Opin Emerg Drugs. 2005 Feb;10(1):119-35.