Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4EHVB)

Drug Name

PPI-668 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Hepatitis C virus Non-structural 5A (HCV NS5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daclatasvir	DMSFK9V	Hepatitis C virus infection	1E51.1	Approved	[3]
Glecaprevir; pibrentasvir	DMF6Z5T	Hepatitis C virus infection	1E51.1	Approved	[4]
ABT-267	DMNQ869	Hepatitis C virus infection	1E51.1	Phase 3	[5]
MK-8742	DMK301H	Hepatitis C virus infection	1E51.1	Phase 3	[6]
Ravidasvir	DM1LFUN	Hepatitis C	1E51	Phase 2/3	[7]
GS-5885	DMSL3DX	Hepatitis C virus infection	1E51.1	Phase 2	[8]
ACH-3102	DM0RPY5	Hepatitis C virus infection	1E51.1	Phase 2	[2]
AZD-2836	DMT2FAP	Hepatitis C virus infection	1E51.1	Phase 1/2	[9]
BMS-824383	DMPQ5XC	Hepatitis C virus infection	1E51.1	Phase 1	[3]
PPI-461	DMTOXLG	Hepatitis C virus infection	1E51.1	Phase 1	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis C virus Non-structural 5A (HCV NS5A)	TTCJ2X8	POLG_HCV1	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01859962) Study of PPI-668, BI 207127 and Faldaprevir, With and Without Ribavirin, in the Treatment of Chronic Hepatitis C. U.S. National Institutes of Health.
2	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
3	2011 Pipeline of Bristol-Myers Squibb.
4	2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
5	Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A. J Med Chem. 2014 Mar 13;57(5):2047-57.
6	Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity. ChemMedChem. 2013 Dec;8(12):1930-40.
7	Clinical pipeline report, company report or official report of Presidio Pharmaceuticals.
8	Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection. J Med Chem. 2014 Mar 13;57(5):2033-46.
9	TARGETING THE NS5A PROTEIN OF HCV: AN EMERGING OPTION. Drugs Future. 2011 September; 36(9): 691-711.