Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4K085)

Drug Name

AZD-3778 Drug Info

Synonyms

AZD-3778; CHEMBL2158814; SCHEMBL5418656; GTPL7679; AZD3778; QVLZVRFIGXNZMN-UHFFFAOYSA-N; AZD 3778; BDBM50394155; N-[[4-(3,4-Dichlorophenoxy)[1,4'-bipiperidin]-1'-yl]carbonyl]-4-methyl-benzenesulfonamide

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 11753159
TTD Drug ID: DM4K085

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

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Drug(s) Targeting Chemokine receptor (CHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD-8309	DMW6IUB	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 1	[3]
AZD-4750	DMQ2VYT	Multiple sclerosis	8A40	Discontinued in Phase 1	[4]
AZD-7140	DMX63W1	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 1	[5]
AZD-0275	DMJH7IX	Chronic obstructive pulmonary disease	CA22	Terminated	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Chemokine receptor (CHR)	TTQR8Z6	NOUNIPROTAC	Modulator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7679).
2	New Drugs and Targets for Asthma and COPD. Trevor T. Hansel, Peter J. Barnes. 2010. Page(304).
3	CXCR2: From Bench to Bedside. Front Immunol. 2012; 3: 263.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018778)
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017126)
6	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019127)