Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4OAIU)

Drug Name

LMI070 Drug Info

Synonyms

branaplam; Branaplam; 1562338-42-4; NVS-SM1; UNII-P12R69543A; LMI-070; P12R69543A; 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol; Branaplam [INN]; SCHEMBL15475826; LMI070 (NVS-SM1); STWTUEAWRAIWJG-UHFFFAOYSA-N; BCP19909; ZINC146605125; AKOS030526592; CS-5319; HY-19620; Phenol, 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethyl-4-piperidinyl)oxy)-3-pyridazinyl)-

Indication

Disease Entry	ICD 11	Status	REF
Spinal muscular atrophy	8B61	Phase 3	[1]

Cross-matching ID

PubChem CID: 135565042
CAS Number: CAS 1562338-42-4
TTD Drug ID: DM4OAIU

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Survival motor neuron protein (SMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolgensma	DM57O90	Spinal muscular atrophy	8B61	Approved	[2]
RG7800	DMAGE91	Spinal muscular atrophy	8B61	Phase 1/2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Survival motor neuron protein (SMN1)	TT8QL6X	SMN_HUMAN	Modulator	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
3	Assays for the Identification and Prioritization of Drug Candidates for Spinal Muscular Atrophy. Assay Drug Dev Technol. 2014 August 1; 12(6): 315-341.