Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4PGRU)

Drug Name

ISIS 23459 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Apoptosis-2 messenger RNA (BIRC3 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SM-337	DMOSTP9	Discovery agent	N.A.	Investigative	[2]
SM-131	DMP8VO6	Discovery agent	N.A.	Investigative	[3]
SM-122	DMC7YQE	Discovery agent	N.A.	Investigative	[2]
ISIS 23452	DM17G39	Discovery agent	N.A.	Investigative	[1]
ISIS 23454	DM7FPZV	Discovery agent	N.A.	Investigative	[1]
ISIS 23414	DMOC0DT	Discovery agent	N.A.	Investigative	[1]
ISIS 23416	DMHQD76	Discovery agent	N.A.	Investigative	[1]
ISIS 23412	DMJ0LB1	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis-2 messenger RNA (BIRC3 mRNA)	TTAIWZN	BIRC3_HUMAN	Not Available	[1]

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References

1	US patent application no. 5,958,771, Antisense modulation of cellular inhibitor of Apoptosis-2 expression.
2	Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7.
3	Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of ca... J Med Chem. 2008 Dec 11;51(23):7352-5.