Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4T8KV)

Drug Name
RQ-00201894 Drug Info
Synonyms Motilin receptor agonists (GERD), RaQualia; Motilin receptor agonists (gastroesophageal reflux), RaQualia
Indication
Disease Entry ICD 11 Status REF
Gastroesophageal reflux disease DA22.Z Investigative [1]
Cross-matching ID
TTD Drug ID
DM4T8KV

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Motilin receptor (MLNR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MOTILIN DMVILAD N. A. N. A. Phase 4 [2]
Camicinal DMAKSMX Delayed gastric emptying DA41.00 Phase 2 [1]
Mitemcinal fumarate DMOJ7QA Pain MG30-MG3Z Phase 2 [3]
RWJ-68023 DM4O07Q Irritable bowel syndrome DD91.0 Phase 1 [4]
KOS-2187 DM4953W Gastroesophageal reflux disease DA22.Z Phase 1 [5]
DS-3801 DM6WN9X Constipation DD91.1 Phase 1 [6]
GSK-1322888 DMNYGB8 Gastroparesis DA41.00 Phase 1 [7]
KW-5139 DMLOKXI Pain MG30-MG3Z Discontinued in Phase 2 [8]
KC-11458 DMOITN2 Gastric motility disorder DA21 Discontinued in Phase 2 [9]
SLV-305 DMBZM0D Gastric motility disorder DA21 Discontinued in Phase 2 [1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Motilin receptor (MLNR) TT953CX MTLR_HUMAN Agonist [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297).
2 Discovery of a new class of macrocyclic antagonists to the human motilin receptor. J Med Chem. 2006 Nov 30;49(24):7190-7.
3 Clinical pipeline report, company report or official report of Roche (2009).
4 Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function. Br J Clin Pharmacol. 2004 Apr;57(4):393-401.
5 Kosan Announces Selection of KOS-2187 As Motilide Clinical Candidate at World Congress of Gastroenterology Meeting. Kosan. 2006.
6 Clinical pipeline report, company report or official report of Daiichi Sankyo.
7 ClinicalTrials.gov (NCT01294566) FTIH to Evaluate Safety, Tolerability, and Pharmacokinetics of Single Oral Doses of GSK1322888 in Healthy Caucasian and Japanese Volunteers. U.S. National Institutes of Health.
8 Stimulating action of KW-5139 (Leu13-motilin) on gastrointestinal motility in the rabbit. Br J Pharmacol. 1994 Jan;111(1):288-94.
9 Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis. Aliment Pharmacol Ther. 2004 Aug 1;20(3):333-8.