Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4U5NF)

Drug Name

ISIS-TTR Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Amyloidosis	5D00	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Transthyretin messenger RNA (TTR mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Patisiran	DMWSA0V	Amyloidosis	5D00	Approved	[3]
Vutrisiran	DMM1Z9G	Hereditary amyloidosis	5D00.2	Approved	[4]
Eplontersen	DMON9CY	Amyloid polyneuropathy	5D00.20	Approved	[5]
Revusiran	DM5E73H	Amyloidosis	5D00	Phase 3	[3]
ALN-TTR01	DMCSEUY	Amyloidosis	5D00	Phase 1	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transthyretin messenger RNA (TTR mRNA)	TTPOYU7	TTHY_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT02175004) Open-Label Extension Assessing Long Term Safety and Efficacy of ISIS-TTR Rx in Familial Amyloid Polyneuropathy (FAP). U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
3	Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc.
4	Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals.
5	FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 217388
6	Safety and efficacy of RNAi therapy for transthyretin amyloidosis. N Engl J Med. 2013 Aug 29;369(9):819-29.