Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM508BS)

• Drug Name: ISIS 109351 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DM508BS

Molecule-Related Drug Atlas

Drug(s) Targeting PKC-theta messenger RNA (PRKCQ mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PROSTRATIN	DM1HMJ5	Human immunodeficiency virus infection	1C62	Investigative	[2]
8-Octyl-benzolactam-V9	DM4Z15M	Discovery agent	N.A.	Investigative	[3]
ISIS 109352	DMWK1XC	Discovery agent	N.A.	Investigative	[1]
ISIS 109353	DM6AJMC	Discovery agent	N.A.	Investigative	[1]
ISIS 109355	DMFIQGW	Discovery agent	N.A.	Investigative	[1]
4-(1H-indol-6-ylamino)-5-styrylnicotinonitrile	DMB07TU	Discovery agent	N.A.	Investigative	[4]
4-(1H-indol-5-yloxy)-5-styrylnicotinonitrile	DMH360U	Discovery agent	N.A.	Investigative	[4]
ISIS 109354	DM1REKQ	Discovery agent	N.A.	Investigative	[1]
4-(1H-indol-5-ylamino)-5-styrylnicotinonitrile	DMAU0SF	Discovery agent	N.A.	Investigative	[4]
4-(3H-indol-4-ylamino)-5-styrylnicotinonitrile	DMM8AY5	Discovery agent	N.A.	Investigative	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PKC-theta messenger RNA (PRKCQ mRNA)	TT1MS7X	KPCT_HUMAN	Not Available	[1]

References

• [1] US patent application no. 6,190,869, Antisense inhibition of protein kinase C-theta expression.
• [2] A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86.
• [3] Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8.
• [4] First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32.