Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM50WFM)

Drug Name
[3H]5-oxo-ETE Drug Info
Synonyms
5-Oxo-ETE; 5-Oxoete; 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; 5-Kete; 5-Oxoeicosatetraenoic acid; 5-ketoeicosatetraenoic acid; CHEMBL18028; CHEBI:52449; (6E,8Z,11Z,14Z)-5-Oxoicosa-6,8,11,14-tetraenoic acid; 106154-18-1; 5-Oxo-eicosatetraenoate; 5-Oxoicosatetraenoic acid; [3H]-5-oxo-ETE; 5-Keto-6,8,11,14-eicosatetraenoic acid; 5-keto-ETE; ETE-5-Oxo; AC1NR1NN; BSPBio_001453; SCHEMBL139762; BML1-D12; GTPL3391; GTPL3416; MEASLHGILYBXFO-XTDASVJISA-N; HMS3402I15; HMS1791I15; HMS1989I15; HMS1361I15; ZINC4655377; LMFA03060011; [3H]-5-oxo-ETE; 5-oxo-ETE
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5283159
ChEBI ID
CHEBI:52449
CAS Number
CAS 106154-18-1
TTD Drug ID
DM50WFM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Oxoeicosanoid receptor 1 (OXER1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
5S-HETE DM3Z6G4 Discovery agent N.A. Investigative [3]
5S-HPETE DME1304 Discovery agent N.A. Investigative [3]
5-oxo-C20:3 DM6FSUW Discovery agent N.A. Investigative [4]
5-(6-chloro-2-hexyl-1H-indol-1-yl)-5-oxo-valeric acid DM0K7U5 Discovery agent N.A. Investigative [5]
5-oxo-12-HETE DMLABR9 Discovery agent N.A. Investigative [6]
5-oxo-15-HETE DM9ZC7B Discovery agent N.A. Investigative [7]
Gue1654 DM89KNT Discovery agent N.A. Investigative [8]
5-oxo-ODE DM56TVA Discovery agent N.A. Investigative [9]
5-oxo-20-HETE DM493GU Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Oxoeicosanoid receptor 1 (OXER1) TT7WBSV OXER1_HUMAN Agonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3391).
2 Receptors for the 5-oxo class of eicosanoids in neutrophils. J Biol Chem. 1998 Dec 4;273(49):32535-41.
3 TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis. Biochem Biophys Res Commun. 2005 Sep 9;334(4):987-95.
4 Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity. J Pharmacol Exp Ther. 2008 May;325(2):698-707.
5 5-Oxo-ETE receptor antagonists. J Med Chem. 2013 May 9;56(9):3725-32.
6 Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets. Blood. 1999 Feb 1;93(3):1086-96.
7 Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils. J Immunol. 1996 Jan 1;156(1):336-42.
8 A biased ligand for OXE-R uncouples Galpha and Gbetagamma signaling within a heterotrimer. Nat Chem Biol. 2012 Jul;8(7):631-8.
9 Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant. J Biol Chem. 2008 Apr 25;283(17):11234-43.