Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM53Z4I)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Endoplasmic reticulum to nucleus signaling 1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ORIN1001	DM27RXS	Metastatic breast cancer	2C6Y	Phase 1/2	[2]
T8361	DM86BDS	N. A.	N. A.	Patented	[3]
US8614253, 29-1	DMJKFVU	N. A.	N. A.	Patented	[4]
US8614253, 32-5	DMSQODK	N. A.	N. A.	Patented	[3]
US8614253, 29-19	DMVI83P	N. A.	N. A.	Patented	[5]
879325-11-8	DMP04Z6	N. A.	N. A.	Patented	[1]
AC1LE05K	DMPOR3G	N. A.	N. A.	Patented	[6]
US8614253, 32-4	DMRSP2M	N. A.	N. A.	Patented	[5]
BB 0223767	DM2DT6L	N. A.	N. A.	Patented	[3]
US9241942, 32-12	DM8GW54	N. A.	N. A.	Patented	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endoplasmic reticulum to nucleus signaling 1 (ERN1)	TTOJ9QL	ERN1_HUMAN	Inhibitor	[1]

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References

1	IRE-1 inhibitors. US9040714.
2	Clinical pipeline report, company report or official report of Orinove.
3	IRE-1 inhibitors. US8614253.
4	IRE-1 inhibitors. US9241942.
5	IRE-1 inhibitors. US9493435.
6	IRE-1 inhibitors. US9693992.