Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM548TK)

Drug Name

Belumosudil Drug Info

Synonyms

KD025

Indication

Disease Entry	ICD 11	Status	REF
Graft-versus-host disease	4B24	Approved	[1]
Psoriasis vulgaris	EA90	Phase 2	[2]
Rheumatoid arthritis	FA20	Phase 2	[3]
Psoriatic arthritis	FA21	Phase 1	[4]
Scleroderma	4A42	Phase 1	[4]
Systemic lupus erythematosus	4A40.0	Phase 1	[4]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Rho-associated protein kinase 2 (ROCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
INS-117548	DMA46DO	Glaucoma/ocular hypertension	9C61	Phase 1	[6]
GSK269962A	DM5I2HL	Inflammation	1A00-CA43.1	Clinical trial	[7]
PMID28048944-Compound-19	DMPT3V9	N. A.	N. A.	Patented	[8]
PMID28048944-Compound-3	DM1BN74	N. A.	N. A.	Patented	[8]
PMID28048944-Compound-7	DMXZ368	N. A.	N. A.	Patented	[8]
PMID28048944-Compound-4	DMJAUWG	N. A.	N. A.	Patented	[8]
PMID28048944-Compound-5	DMAB987	N. A.	N. A.	Patented	[8]
PMID28048944-Compound-6	DM5RCBV	N. A.	N. A.	Patented	[8]
PMID28048944-Compound-2	DM9ZXOP	N. A.	N. A.	Patented	[8]
Tricyclic compound 7	DME84S5	N. A.	N. A.	Patented	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Rho-associated protein kinase 2 (ROCK2)	TTGWKQJ	ROCK2_HUMAN	Inhibitor	[5]

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References

1	FDA Approved Drug Products from FDA Official Website. 2021. Application Number: 214783.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	ClinicalTrials.gov (NCT02317627) Study of of KD025 in Subjects With Psoriasis Vulgaris Who Failed First-Line Therapy. U.S. National Institutes of Health.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16814-9.
6	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
7	Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.
8	Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515.