Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM54MDH)

• Drug Name: 3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol Drug Info
• Synonyms: CHEMBL541643

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9901372
  CAS Number: CAS 371943-05-4
  TTD Drug ID: DM54MDH

Molecule-Related Drug Atlas

Drug(s) Targeting PI3K p110 beta messenger RNA (PIK3CB mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY-292223	DML36ZE	Discovery agent	N.A.	Investigative	[2]
Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate	DM3FH02	Discovery agent	N.A.	Investigative	[2]
ISIS 32014	DMF5SK8	Discovery agent	N.A.	Investigative	[3]
ISIS 32024	DMPKGIU	Discovery agent	N.A.	Investigative	[3]
ISIS 32035	DM47B2O	Discovery agent	N.A.	Investigative	[3]
ISIS 32000	DM0O9WM	Discovery agent	N.A.	Investigative	[3]
ISIS 32021	DMISB5V	Discovery agent	N.A.	Investigative	[3]
ISIS 32003	DM7EVQX	Discovery agent	N.A.	Investigative	[3]
ISIS 32028	DMATWDO	Discovery agent	N.A.	Investigative	[3]
ISIS 32039	DMY1R0Q	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting PI3-kinase gamma (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[4]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[5]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[6]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[7]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[8]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[7]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[9]
SAR245409	DMQM7IL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
XL147	DMML7BE	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
SF1126	DML10K3	Head and neck cancer	2D42	Phase 2	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Inhibitor	[1]
PI3K p110 beta messenger RNA (PIK3CB mRNA)	TT9H4P3	PK3CB_HUMAN	Inhibitor	[1]

References

• [1] Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2007 Sep 1;15(17):5837-44.
• [2] LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13.
• [3] US patent application no. 6,133,032, Antisense modulation of PI3 kinase p110 beta expression.
• [4] BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110 and p110 activities in tumor cell lines and xenograft models.Mol Cancer Ther.2013 Nov;12(11):2319-30.
• [5] PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74.
• [6] Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44.
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies. Clin Cancer Res. 2014 Mar 15;20(6):1656-65.
• [9] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155).
• [10] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2156).
• [11] An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.Cancer Chemother Pharmacol.2013 Apr;71(4):867-81.