Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM572ZL)

Drug Name

BBP-398 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Protein-tyrosine phosphatase SHP-2 (PTPN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JAB-3312	DMNMV0D	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]
TNO155	DMZ60X4	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
JAB-3068	DMSGEU6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
SAR442720	DMTAOPC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
RLY-1971	DMUT4YZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
PF-07284892	DMQ6F8X	Aggressive cancer	2A00-2F9Z	Phase 1	[6]
A380	DMXOZDP	Aggressive cancer	2A00-2F9Z	Phase 1	[7]
RG6433	DMZM06U	Aggressive cancer	2A00-2F9Z	Phase 1	[8]
NSC-87877	DMEYKXL	Discovery agent	N.A.	Patented	[9]
Dodecane-Trimethylamine	DMUPMCZ	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein-tyrosine phosphatase SHP-2 (PTPN11)	TT7WUAV	PTN11_HUMAN	Inhibitor	[1]

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References

1	ClinicalTrials.gov (NCT04528836) First-in-Human Study of the SHP2 Inhibitor BBP-398 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of AbbVie.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of Revolution Medicines.
5	Clinical pipeline report, company report or official report of Relay Therapeutics.
6	SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy. Cancer Discov. 2023 Aug 4;13(8):1789-1801.
7	Clinical pipeline report, company report or official report of Klus Pharma
8	Clinical pipeline report, company report or official report of Roche
9	Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem. 2008 Aug 28;51(16):4948-56.
10	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.