Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM57HM7)

Drug Name
PBKR03 Drug Info
Indication
Disease Entry ICD 11 Status REF
Globoid cell leukodystrophy 8A44.4 Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DM57HM7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Galactocerebrosidase (GALC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
FBX-101 DMZR3OJ Krabbe disease 8A44.4 Phase 1/2 [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Galactocerebrosidase (GALC) TT5IZRB GALC_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT04771416) A Phase 1/2 Open-Label, Multicenter Dose-Ranging and Confirmatory Study to Assess the Safety, Tolerability and Efficacy of PBKR03 Administered to Pediatric Subjects With Early Infantile Krabbe Disease (Globoid Cell Leukodystrophy). U.S.National Institutes of Health.
2 Clinical pipeline report, company report or official report of Passage Bio
3 ClinicalTrials.gov (NCT04693598) A Phase 1/2 Clinical Study of Intravenous Gene Transfer With an AAVrh10 Vector Expressing GALC in Krabbe Subjects Receiving Hematopoietic Stem Cell Transplantation (RESKUE). U.S.National Institutes of Health.