Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5AIKR)

Drug Name

RGX-104 Drug Info

Synonyms

Rgx-104 hydrochloride; RGX-104 hydrochloride; 610318-03-1; UNII-D32013XLTX; SCHEMBL3975944; D32013XLTX; LCMIYQOJZLRHTO-GJFSDDNBSA-N; (r)-2-(3-{3-[[2chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methyl-propoxy}-phenyl)acetic acid hydrochloride salt

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25.Y	Phase 1/2	[1]
Lymphoma	2A80-2A86	Phase 1	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

Cross-matching ID

PubChem CID: 68861574
CAS Number: CAS 610318-03-1
TTD Drug ID: DM5AIKR

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Oxysterols receptor LXR (NR1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALX-101	DMCAFXM	Atopic dermatitis	EA80	Phase 2	[3]
BMS-779788	DMKR8S1	Arteriosclerosis	BD40	Phase 1	[4]
CS-8080	DMRH740	Arteriosclerosis	BD40	Phase 1	[4]
BMS-852927	DMZS1D2	Arteriosclerosis	BD40	Phase 1	[4]
XL-041	DMYSQHT	Arteriosclerosis	BD40	Phase 1	[5]
XL652/XL014	DM89NML	Cardiovascular disease	BA00-BE2Z	Phase 1	[6]
LXR 623	DM3OP41	Arteriosclerosis	BD40	Phase 1	[4]
T0901317	DMZQVDI	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxysterols receptor LXR (NR1H)	TTM1EQF	NOUNIPROTAC	Agonist	[2]

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References

1	Clinical pipeline report, company report or official report of Rgenix.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014 Jun;13(6):433-44.
5	Emerging small molecule drugs. Handb Exp Pharmacol. 2015;224:617-30.
6	Clinical pipeline report, company report or official report of Exelixis (2011).
7	The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res. 2003 Nov;44(11):2039-48.