Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5BQK3)

Drug Name

NBI-34041 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Eating disorder	6B82	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Corticotropin-releasing factor receptor 2 (CRHR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Urocortin 2	DM0YO4Q	Congestive heart failure	BD10	Phase 2	[2]
RT-400	DM8DVC9	Acute decompensated heart failure	BD1Z	Phase 2	[3]
PF-572778	DMZ8HW7	Generalized anxiety disorder	6B00	Terminated	[4]
SC-241	DM7I6VO	Anxiety disorder	6B00-6B0Z	Terminated	[5]
astressin	DMSFLTK	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticotropin-releasing factor receptor 2 (CRHR2)	TTIY658	CRFR2_HUMAN	Antagonist	[1]

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References

1	Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36.
2	Evolution of complementary peptide systems: teneurin C-terminal-associated peptides and corticotropin-releasing factor superfamilies. Ann N Y Acad Sci. 2009 Apr;1163:215-20.
3	Advances in therapeutic peptides targeting G protein-coupled receptors. Nat Rev Drug Discov. 2020 Jun;19(6):389-413.
4	WO patent application no. 2013,1603,15, Genetic predictors of response to treatment with crhr1 antagonists.
5	US patent application no. 2015,0094,310, Crhr1 antagonists for use in the treatment of patients having crh overactivity.
6	Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors. J Pharmacol Exp Ther. 1999 Feb;288(2):729-34.