Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5EWIK)

Drug Name

NEODYSIDENIN Drug Info

Synonyms

neodysidenin; CHEMBL392270

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Arachidonate 12-lipoxygenase (12-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[1]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[2]
MANGOSTIN	DMYQGDV	Discovery agent	N.A.	Investigative	[1]
PUUPEHENONE	DMF3BCK	Discovery agent	N.A.	Investigative	[3]
Isojaspic acid	DMHTBDN	Discovery agent	N.A.	Investigative	[2]
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol	DMLDQWT	Discovery agent	N.A.	Investigative	[3]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol	DMO34LJ	Discovery agent	N.A.	Investigative	[4]
NSC-292213	DMNUSKT	Discovery agent	N.A.	Investigative	[1]
Jaspic acid	DMOF0TB	Discovery agent	N.A.	Investigative	[3]
DYSIDENIN	DMIZQTX	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 12-lipoxygenase (12-LOX)	TT12ABZ	LOX12_HUMAN	Inhibitor	[1]

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References

1	Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
2	Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.
3	Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5.
4	Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.