Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5GAC4)

• Drug Name: SRD-441 Drug Info
• Synonyms: Aureostat; ST-441; STP-01a; Protease inhibitor (atopic dermatitis), Surface Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Atopic dermatitis	EA80	Phase 2	[1]

• Cross-matching ID: TTD Drug ID: DM5GAC4

Molecule-Related Drug Atlas

Drug(s) Targeting Protease unspecific (PRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prolastin	DMYSCIL	Alpha-1 antitrypsin deficiency	5C5A	Approved	[3]
ONO-3307	DMQGO74	Coagulation defect	3B10.0	Phase 2	[4]
AZD-2551	DMZQEDY	Chronic obstructive pulmonary disease	CA22	Phase 1	[5]
AZD-3342	DMUCQPB	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 1	[6]
Aprosulate sodium	DMRLHNW	Coagulation defect	3B10.0	Discontinued in Phase 1	[7]
EP-2060	DMZA5Q4	Solid tumour/cancer	2A00-2F9Z	Terminated	[8]
CEP-431	DMDH0AM	Alzheimer disease	8A20	Terminated	[9]
WY-48989	DMGJNQW	Rheumatoid arthritis	FA20	Terminated	[10]
ALP-242	DM592WE	Cystic fibrosis	CA25	Terminated	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protease unspecific (PRO)	TTZBFA0	NOUNIPROTAC	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT00882245) Safety and Efficacy of SRD441 Ointment in Patients With Atopic Dermatitis. U.S. National Institutes of Health.
• [2] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029807)
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [4] Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo. Jpn J Pharmacol. 1989 Dec;51(4):455-63.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029854)
• [6] New Drugs and Targets for Asthma and COPD. Trevor T. Hansel, Peter J. Barnes. 2010. Page(227).
• [7] Interaction between the sulfated lactobionic acid (LW 10082) and other antithrombotic agents in animal thrombosis model. Pol J Pharmacol. 1996 May-Jun;48(3):317-22.
• [8] Discovery of 4-aryl-4H-chromenes as potent apoptosis inducers using a cell- and caspase-based Anti-cancer Screening Apoptosis Program (ASAP): SAR studies and the identification of novel vascular disrupting agents. Anticancer Agents Med Chem. 2009 May;9(4):437-56.
• [9] US patent application no. 7,935,815, Imidazoyl pyridine compounds and salts thereof.
• [10] Inhibition of interleukin-1 (IL-1) induced neutral proteases from rabbit articular chondrocytes by WY-46,135 and WY-48,989. Agents Actions. 1991 Sep;34(1-2):223-5.
• [11] Oxidation resistant muteins of antileukoproteinase as potential therapeutic agents. Agents Actions Suppl. 1993;42:111-21.