Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5HO2X)

Drug Name

Ponsegromab Drug Info

Synonyms

PF-06946860

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CIN-109	DMZTPX3	Obesity	5B81	Phase 1	[4]
CIN-209	DMBK5CQ	Obesity	5B81	Preclinical	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Growth/differentiation factor 15 (GDF15)	TT4MXVG	GDF15_HUMAN	Inhibitor	[3]

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References

1	ClinicalTrials.gov (NCT05546476) A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO INVESTIGATE THE EFFICACY, SAFETY AND TOLERABILITY OF PONSEGROMAB IN PATIENTS WITH CANCER, CACHEXIA, AND ELEVATED CONCENTRATIONS OF GDF-15, FOLLOWED BY AN OPTIONAL OPEN-LABEL TREATMENT PERIOD (PROACC -1). U.S.National Institutes of Health.
2	ClinicalTrials.gov (NCT05492500) A PHASE 2, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, 4-ARM STUDY TO INVESTIGATE SYMPTOMS, FUNCTION, HEALTH-RELATED QUALITY OF LIFE AND SAFETY WITH REPEATED SUBCUTANEOUS ADMINISTRATION OF PONSEGROMAB VERSUS PLACEBO IN ADULT PARTICIPANTS WITH HEART FAILURE. U.S.National Institutes of Health.
3	Current advancements in pharmacotherapy for cancer cachexia. Expert Opin Pharmacother. 2023 Apr;24(5):629-639.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
5	Clinical pipeline report, company report or official report of CinFina Pharma