Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5QZDL)

Drug Name
3-Hydroxy-4-phenyl-5H-furan-2-one Drug Info
Synonyms CHEMBL295478; 6362-76-1; 3-Hydroxy-4-phenylfuran-2(5H)-one; CTK2A8725; DTXSID60446001; 3-hydroxy-4-phenyl-2(5h)-furanone; 2(5H)-Furanone, 3-hydroxy-4-phenyl-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10103675
TTD Drug ID
DM5QZDL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Hydroxyphenylpyruvate dioxygenase (HPD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitisinone DMVS9WQ Hereditary tyrosinemia type 1 5C50.11 Approved [2]
BMS-433771 DME20VP Respiratory syncytial virus infection 1C80 Terminated [3]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [4]
2-(2-Nitro-benzoyl)-cyclohexane-1,3-dione DMUJQX1 Discovery agent N.A. Investigative [5]
2-(2-Iodo-benzoyl)-cyclohexane-1,3-dione DMSVHU9 Discovery agent N.A. Investigative [5]
2-(2-Bromo-benzoyl)-cyclohexane-1,3-dione DM3VH7F Discovery agent N.A. Investigative [5]
Diketonitrile DMPKQER Discovery agent N.A. Investigative [6]
2-(2-Methoxy-benzoyl)-cyclohexane-1,3-dione DMESMBO Discovery agent N.A. Investigative [5]
(4-Hydroxy-phenoxy)-acetic acid DMRCM5O Discovery agent N.A. Investigative [1]
2-(2-Chloro-benzoyl)-cyclohexane-1,3-dione DMG6ABE Discovery agent N.A. Investigative [5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hydroxyphenylpyruvate dioxygenase (HPD) TT8DSFC HPPD_HUMAN Inhibitor [1]

References

1 Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1709-13.
2 Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother. 2008 May;9(7):1229-36.
3 Emerging drugs for respiratory syncytial virus infection. Expert Opin Emerg Drugs. 2009 Jun;14(2):207-17.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5.
6 4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target. Drug News Perspect. 2003 Oct;16(8):493-6.