Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5SM8X)

Drug Name
3'-THIO-THYMIDINE-5'-PHOSPHATE Drug Info
Synonyms
3'-THIO-THYMIDINE-5'-PHOSPHATE; DB08651; 3'-thiothymidine 5'-(dihydrogen phosphate); 3'-Mercapto-3'-deoxythymidine 5'-phosphoric acid; [(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3H-pyrimidin-1-yl)-3-sulfanyloxolan-2-yl]methoxyphosphonic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
46937170
TTD Drug ID
DM5SM8X

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase II beta (TOP2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexrazoxane DMD7X1O Breast cancer 2C60-2C65 Approved [2]
XK-469 DMVYO41 Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
XB-947 DM1UIOA Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
A-62176 DM4WT7Z N. A. N. A. Terminated [5]
AMP-PNP DMTOK1D Discovery agent N.A. Investigative [1]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase II beta (TOP2B) TT4NVEM TOP2B_HUMAN Inhibitor [1]

References

1 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.Pharmacogenet Genomics.2014 Feb;24(2):129-32.
4 XK469, a selective topoisomerase IIbeta poison. Proc Natl Acad Sci U S A. 1999 October 12; 96(21): 12168-12173.
5 Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model. J Med Chem. 1998 Oct 22;41(22):4273-8.