Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5TB76)

Drug Name

DACRA 089 Drug Info

Synonyms

KBP-089

Indication

Disease Entry	ICD 11	Status	REF
Type 2 diabetes	5A11	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Amylin receptor (IAPPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Davalintide	DM9S3R8	Obesity	5B81	Discontinued in Phase 2	[3]
AC-253	DM704HO	Hypertension	BA00-BA04	Discontinued in Phase 1	[4]
AC-625	DMIJB68	Hypertension	BA00-BA04	Discontinued in Phase 1	[4]
AC-187	DM5IDAQ	Type-2 diabetes	5A11	Terminated	[5]
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Drug(s) Targeting Calcitonin receptor (CALCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitonin Human	DM0N9WA	Paget's disease	FB85	Approved	[6]
Salmon Calcitonin	DMEWUPF	Bone Paget disease		Approved	[7]
LY 3541105	DMJ1X85	Obesity	5B81	Phase 1	[8]
TJN-220	DM4YQDX	Hypertension	BA00-BA04	Terminated	[9]
CSNLSTCVLGKLSQELc[DKLHK]YPRTNTGSGTP-amide	DMYDTO8	Discovery agent	N.A.	Investigative	[10]
CGNLSTCMLGTYTQDFNKPHTFPQTAIGVGAP-amide	DME84PN	Discovery agent	N.A.	Investigative	[10]
CGNLSTCMLGTYTQDFc[DKFHK]FPQTAIGVGAP-amide	DMUGAYT	Discovery agent	N.A.	Investigative	[10]
CSNLSTCVLGKLSQELc[DKLHO]YPRTNTGSGTP-amide	DMQXEHJ	Discovery agent	N.A.	Investigative	[10]
CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-amide	DMJ9Z31	Discovery agent	N.A.	Investigative	[10]
CGNLSTCBLGTYTQDF[DKFHO]YPQTAIGVGAP-amide	DMQ3SAY	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Amylin receptor (IAPPR)	TTAT87F	CALCR_HUMAN-RAMP1_HUMAN/RAMP2_HUMAN/RAMP3_HUMAN	Agonist	[2]
Calcitonin receptor (CALCR)	TTLWS2O	CALCR_HUMAN	Agonist	[2]

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References

1	ClinicalTrials.gov (NCT03907202) A Clinical Study to Evaluate the Safety, Tolerability, PK, PD, and Efficacy of KBP-089 in Patients With T2DM. U.S. National Institutes of Health.
2	A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. Br J Pharmacol. 2017 Apr;174(7):591-602.
3	Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight. Int J Obes (Lond). 2010 Feb;34(2):385-95.
4	Biotechnology and Its Application in Pharmacy. Kulkarn. 2002. Page157.
5	Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci. 2004 Jun 16;24(24):5579-84.
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7	Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery. Peptides. 2009 Jul;30(7):1288-95.
8	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
9	Evaluation of the long-lasting antihypertensive action of 7-O-ethylfangchinoline. Jpn J Pharmacol. 1994 Sep;66(1):35-46.
10	Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21.