General Information of Drug (ID: DM5UWH3)

Drug Name
PMID22911925C2 Drug Info
Synonyms compound 37 [PMID: 22468684]; GTPL6950; BDBM50397703; 0K9
Indication
Disease Entry ICD 11 Status REF
Diabetic complication 5A2Y Clinical trial [1]
Cross-matching ID
PubChem CID
60202321
TTD Drug ID
DM5UWH3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug(s) Targeting Beta-secretase (BACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
(S)-FLURBIPROFEN DMF2O4T Myalgia FB56.2 Preregistration [3]
E-2609 DMTNUJ8 Alzheimer disease 8A20 Phase 3 [4]
verubecestat DM4CGH5 Alzheimer disease 8A20 Phase 3 [5]
Lanabecestat DMFJLB6 Alzheimer disease 8A20 Phase 3 [6]
AZD3293 DMJQHXD Alzheimer disease 8A20 Phase 2/3 [7]
JNJ-54861911 DMGPJ5U Alzheimer disease 8A20 Phase 2/3 [6]
R-flurbiprofen DMFIVSR N. A. N. A. Phase 2 [3]
LY2886721 DMV14LM Alzheimer disease 8A20 Phase 2 [8]
LY3202626 DM7IFNB Alzheimer disease 8A20 Phase 2 [6]
AZD-3839 DM72FOD Alzheimer disease 8A20 Phase 1 [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Beta-secretase (BACE) TT8JRS7 NOUNIPROTAC Inhibitor [2]

References

1 Design and synthesis of potent, orally efficacious hydroxyethylamine derived beta-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors. J Med Chem. 2012 Nov 8;55(21):9025-44.
2 Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived beta-secretase inhibitors. J Pharmacol Exp Ther. 2012 Nov;343(2):460-7.
3 The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23.
4 Targeting the beta secretase BACE1 for Alzheimer's disease therapy. Lancet Neurol. 2014 March; 13(3): 319-329.
5 BACE1 inhibitor drugs in clinical trials for Alzheimer's disease. Alzheimers Res Ther. 2014 Dec 24;6(9):89.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 AZD3293 A novel BACE1 inhibitor: safety, tolerability, and effects on plasma and CSF A-beta peptides following single- and multiple-dose administration. Neurobiology of Aging. May 20, 2008.
8 Lessons from a BACE1 inhibitor trial: off-site but not off base.Alzheimers Dement.2014 Oct;10(5 Suppl):S411-9.
9 Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. J Biol Chem. 2012 Nov 30;287(49):41245-57.