Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5XUQL)

Drug Name

CPI-613 Drug Info

Synonyms

CPI-613; 95809-78-2; 6,8-bis(benzylthio)octanoic acid; CPI 613; MLS006010202; SCHEMBL1062218; 6,8-Bis(benzylsulfanyl)octanoic acid; Octanoic acid, 6,8-bis((phenylmethyl)thio)-; Octanoic acid, 6,8-bis[(phenylMethyl)thio]-; 6,8-Bis[(phenylmethyl)thio]octanoic acid; CPI613; CHEMBL3186849; QCR-193; AOB1058; MolPort-023-219-128; HMS3656L06; C22H28O2S2; BCP04663; EX-A2043; s2776; AKOS025142095; BCP9000552; DB12109; RL06062; CS-0961; NCGC00344764-01; SMR004701300; AS-16613; BC261916; AK174899; HY-15453; BCP0726000030; KB-293127; AB0035874

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 3	[1]
Pancreatic cancer	2C10	Phase 3	[2]
B-cell lymphoma	2A86	Phase 2	[3]
Myelodysplastic syndrome	2A37	Phase 2	[1]
Recurrent adult burkitt lymphoma	2A85.6	Phase 2	[3]
Metastatic colorectal cancer	2B91	Phase 1	[3]
T-cell lymphoma	2A90	Phase 1	[3]

Cross-matching ID

PubChem CID: 24770514
CAS Number: CAS 95809-78-2
TTD Drug ID: DM5XUQL

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Alpha-ketoglutarate dehydrogenase (OGDH)	TTH8T6I	ODO1_HUMAN	Modulator	[4]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	ClinicalTrials.gov (NCT03504423) Study Evaluating Efficacy and Safety of FFX Versus Combination of CPI-613 With mFFX in Patients With Metastatic Adenocarcinoma of the Pancreas. U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab. 2014 Mar 10;2(1):4.