Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5YF4M)

Drug Name

Droxidopa Drug Info

Synonyms

droxidopa; 23651-95-8; L-DOPS; Northera; (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid; threo-Dopaserine; 3916-18-5; DOPS; DL-threo-DOPS; L-Threodops; DL-threo-3,4-Dihydroxyphenylserine; DL-threo-Droxidopa; DL-threo-Dihydroxyphenylserine; UNII-J7A92W69L7; SM 5688; CHEBI:31524; Droxidopa (L-DOPS); threo-beta,3-Dihydroxy-DL-tyrosine; EINECS 223-480-5; beta,3-Dihydroxy-DL-tyrosine threo-; BRN 2852792; L-threo-dihydroxyphenylserine; DL-threo-3-(3,4-Dihydroxyphenyl)serine; Serine, 3-(3,4-dihydroxyphenyl)-, DL-threo-

Indication

Disease Entry	ICD 11	Status	REF
Neurogenic orthostatic hypotension	8D87.0Y	Approved	[1] , [2] , [3]

Cross-matching ID

PubChem CID: 92974
ChEBI ID: CHEBI:31524
CAS Number: CAS 23651-95-8
TTD Drug ID: DM5YF4M
INTEDE Drug ID: DR0552
ACDINA Drug ID: D00219

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Metabolized By DOPA decarboxylase (DDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[5]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
DOPA decarboxylase (DDC)^{Main DME}	DETK9CN	DDC_HUMAN	Substrate	[4]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7391).
2	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4	L-Dihydroxyphenylserine (L-DOPS): a norepinephrine prodrug. Cardiovasc Drug Rev. 2006 Fall-Winter;24(3-4):189-203.
5	Origin and metabolism of serotonin. J Cardiovasc Pharmacol. 1990;16 Suppl 3:S1-7.
6	Complexity of dopamine metabolism. Cell Commun Signal. 2013 May 17;11(1):34.