Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5ZR4Q)

Drug Name

PSI-938 Drug Info

Synonyms

PSI-352938; PSI-938; UNII-3Z30JH9QX1; 3Z30JH9QX1; PSI938; PSI 938; 1231747-17-3; 1199809-32-9; SCHEMBL2679397; CHEMBL2160007; CS-6672; HY-15231; Guanosine, 2'-deoxy-6-O-ethyl-2'-fluoro-2'-methyl-, cyclic 3',5'-(1-methylethyl (R)-phosphate), (2'R)-; 9-[(4aR,6R,7R,7aR)-7-Fluoro-2-isopropoxy-7-methyl-2-oxo-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-ethoxy-purin-2-amine

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Phase 1	[1]

Cross-matching ID

PubChem CID: 46863668
CAS Number: CAS 1231747-17-3
TTD Drug ID: DM5ZR4Q

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PSI-7977	DMLSUWZ	HCV 1-6 infection	1E51	Approved	[2]
Setrobuvir	DMTNDM2	Hepatitis C virus infection	1E51.1	Phase 2	[3]
BI 207127	DMMSGAT	Hepatitis C virus infection	1E51.1	Phase 2	[4]
Valopicitabine dihydrochloride	DMFWZ2U	Virus infection	1A24-1D9Z	Phase 2	[5]
INX-189	DMSTJ6Q	Hepatitis C virus infection	1E51.1	Phase 2	[6]
Tegobuvir	DM6YI5T	Hepatitis C virus infection	1E51.1	Phase 2	[7]
VX-759	DMJUSM8	Hepatitis C virus infection	1E51.1	Phase 2	[8]
VX-135	DMZ3FE8	Hepatitis C virus infection	1E51.1	Phase 2	[9]
VX-222	DMO3U4W	Hepatitis C virus infection	1E51.1	Phase 2	[8]
BMS 791325	DMKH4PI	Hepatitis C virus infection	1E51.1	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B)	TTMVBWH	POLG_HCV1	Inhibitor	[1]

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References

1	2011 Pipeline of Pharmasset.
2	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
3	Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011).
4	2011 Pipeline of Boehringer Ingelheim Pharma.
5	Valopicitabine dihydrochloride:a specific polymerase inhibitor of hepatitis C virus. Curr Opin Investig Drugs. 2007 Feb;8(2):150-8.
6	Clinical pipeline report, company report or official report of Bristol-Myers Squibb.
7	Clinical pipeline report, company report or official report of Gilead (2011).
8	2011 Pipeline of Vertex.
9	All-oral HCV therapies near approval. Nat Rev Drug Discov. 2013 Jun;12(6):409-11.
10	2011 Pipeline of Bristol-Myers Squibb.