Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM61VHF)

Drug Name

RPR-118071 Drug Info

Synonyms

RPR-118071; CHEMBL93796; 186546-85-0; Benzenecarboximidamide,3-[[(3S)-3-[(2-naphthalenylsulfonyl)amino]-2-oxo-1-pyrrolidinyl]methyl]-; BDBM50080477; ZINC13800223; KB-75023; 3-[3-((S)-Naphthalene-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine; 3-[[3beta-[[(2-Naphthyl)sulfonyl]amino]-2-oxopyrrolizino]methyl]benzamidine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10574241
TTD Drug ID: DM61VHF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Vitamin K-dependent protein C (PROC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium Tetradecyl Sulfate	DM4QFXJ	Hemangioma	2E81-2F2Y	Approved	[2]
Ancrod	DMK2Y4V	Blood forming organ disorder	JB64.1	Phase 3	[3]
3K3A-APC	DMTLR6Y	Cerebrovascular ischaemia	8B1Z	Phase 2	[4]
GED-aPC	DM041IZ	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 1	[5]
RPR-120844	DM1V0MD	Discovery agent	N.A.	Investigative	[1]
PMID24418773C37	DMG4NQV	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vitamin K-dependent protein C (PROC)	TTZUXYS	PROC_HUMAN	Inhibitor	[1]

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References

1	Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa. J Med Chem. 1999 Sep 9;42(18):3557-71.
2	Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
3	Ancrod (Arvin) as an alternative to heparin anticoagulation for cardiopulmonary bypass. Anesthesiology. 1989 Dec;71(6):870-7.
4	Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des. 2012;18(27):4215-22.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2396).
6	Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia. Bioorg Med Chem Lett. 2014 Feb 1;24(3):821-7.