Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM629TD)

Drug Name

NS5818 Drug Info

Synonyms

NS-5818

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Chloride channel protein 7 (ClC-7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[2]
DIDS	DMKSQUB	Discovery agent	N.A.	Investigative	[2]
diphenylamine-2-carboxylic acid	DMBV19T	Discovery agent	N.A.	Investigative	[3]
SITS	DMCMIUG	Discovery agent	N.A.	Investigative	[3]
GTPgammaS	DMJUXKY	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Chloride channel protein 7 (ClC-7)	TTST1AJ	CLCN7_HUMAN	Blocker (channel blocker)	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4275).
2	The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 709).