Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM63QY0)

• Drug Name: SAR292833 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Phase 2	[1]
Insulin-dependent diabetes	5A10	Investigative	[2]

• Cross-matching ID: TTD Drug ID: DM63QY0

Molecule-Related Drug Atlas

Drug(s) Targeting Transient receptor potential cation channel V3 (TRPV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[3]
diphenylboronic anhydride	DMRQZTS	Discovery agent	N.A.	Investigative	[4]
citral	DM53ZGY	Discovery agent	N.A.	Investigative	[5]
aspirin-triggered resolvin D1	DMOP941	Discovery agent	N.A.	Investigative	[6]
carvacrol	DMINM2D	Discovery agent	N.A.	Investigative	[7]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[8]
diphenyltetrahydrofuran	DMK8T61	Discovery agent	N.A.	Investigative	[4]
carveol	DMGIZ5U	Discovery agent	N.A.	Investigative	[9]
dihydrocarveol	DMS4U68	Discovery agent	N.A.	Investigative	[9]
tetrahydrocannabivarin	DMDY1MZ	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transient receptor potential cation channel V3 (TRPV3)	TT946IA	TRPV3_HUMAN	Modulator	[1]

References

• [1] Pharmacological profiling of the TRPV3 channel in recombinant and native assays. Br J Pharmacol. 2014 May;171(10):2631-44.
• [2] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [3] 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci. 2004 Jun 2;24(22):5177-82.
• [4] Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J Biol Chem. 2005 Apr 22;280(16):15928-41.
• [5] Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 7;3(5):e2082.
• [6] 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92.
• [7] Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-35.
• [8] More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci. 2006 Aug;32(4):335-43.
• [9] Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40.
• [10] Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation. Acta Physiol (Oxf). 2012 Feb;204(2):255-66.