Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM64FX9)

Drug Name

JTK-853 Drug Info

Synonyms

JTK-853; UNII-WDX8QQD13B; WDX8QQD13B; 954389-09-4; (2r)-4-(5-Cyclopropyl[1,3]thiazolo[4,5-D]pyrimidin-2-Yl)-N-[3-Fluoro-4-(Trifluoromethoxy)benzyl]-1-{[4-(Trifluoromethyl)phenyl]sulfonyl}piperazine-2-Carboxamide; 3vqs; JTK 853; SCHEMBL2440999; DTXSID60241836; JQLOVYLALGSISI-HXUWFJFHSA-N; DB13095; HY-19921; 2-Piperazinecarboxamide, 4-(5-cyclopropylthiazolo(4,5-d)pyrimidin-2-yl)-n-((3-fluoro-4-(trifluoromethoxy)phenyl)methyl)-1-((4-(trifluoromethyl)phenyl)sulfonyl)-, (2R)-; CS-0016935; JT1

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Discontinued in Phase 1	[1]

Cross-matching ID

PubChem CID: 57519700
CAS Number: CAS 954389-09-4
TTD Drug ID: DM64FX9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PSI-7977	DMLSUWZ	HCV 1-6 infection	1E51	Approved	[3]
Setrobuvir	DMTNDM2	Hepatitis C virus infection	1E51.1	Phase 2	[4]
BI 207127	DMMSGAT	Hepatitis C virus infection	1E51.1	Phase 2	[5]
Valopicitabine dihydrochloride	DMFWZ2U	Virus infection	1A24-1D9Z	Phase 2	[6]
INX-189	DMSTJ6Q	Hepatitis C virus infection	1E51.1	Phase 2	[7]
Tegobuvir	DM6YI5T	Hepatitis C virus infection	1E51.1	Phase 2	[8]
VX-759	DMJUSM8	Hepatitis C virus infection	1E51.1	Phase 2	[9]
VX-135	DMZ3FE8	Hepatitis C virus infection	1E51.1	Phase 2	[10]
VX-222	DMO3U4W	Hepatitis C virus infection	1E51.1	Phase 2	[9]
BMS 791325	DMKH4PI	Hepatitis C virus infection	1E51.1	Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B)	TTMVBWH	POLG_HCV1	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032147)
2	Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase. Antimicrob Agents Chemother. 2012 August; 56(8): 4250-4256.
3	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
4	Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011).
5	2011 Pipeline of Boehringer Ingelheim Pharma.
6	Valopicitabine dihydrochloride:a specific polymerase inhibitor of hepatitis C virus. Curr Opin Investig Drugs. 2007 Feb;8(2):150-8.
7	Clinical pipeline report, company report or official report of Bristol-Myers Squibb.
8	Clinical pipeline report, company report or official report of Gilead (2011).
9	2011 Pipeline of Vertex.
10	All-oral HCV therapies near approval. Nat Rev Drug Discov. 2013 Jun;12(6):409-11.
11	2011 Pipeline of Bristol-Myers Squibb.