Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM64LVS)

Drug Name
ICT-121 Drug Info
Indication
Disease Entry ICD 11 Status REF
Recurrent glioblastoma 2A00.00 Phase 1 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Cross-matching ID
TTD Drug ID
DM64LVS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prominin-1 (PROM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anti-CD133-CAR vector-transduced T cells DMGUM90 Brain cancer 2A00 Phase 1 [4]
CAR-T cells targeting CD133 DMYOR5T Acute myeloid leukaemia 2A60 Preclinical [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prominin-1 (PROM1) TTXMZ81 PROM1_HUMAN Not Available [3]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT02049489) A Study of ICT-121 Dendritic Cell Vaccine in Recurrent Glioblastoma. U.S. National Institutes of Health.
3 Immunotargeting of cancer stem cells. Contemp Oncol (Pozn) 2015; 19(1A): A52-A59.
4 ClinicalTrials.gov (NCT02541370) Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART133
5 ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia