Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM64WYC)

Drug Name

ATX-101 Drug Info

Synonyms

ATX-101, APIM Therapeutics; Proliferating cell nuclear antigen (peptide, cancer), APIM

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ChelASE	DM0JUAL	Retina disorder	9B70-9B7Z	Discontinued in Phase 1	[3]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proliferating cell nuclear antigen (PCNA)	TTLG1PD	PCNA_HUMAN	Immunomodulator	[2]

------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 610).
2	Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells. PLoS One. 2013 Jul 31;8(7):e70430.
3	Safety and efficacy assessment of chimeric ribozyme to proliferating cell nuclear antigen to prevent recurrence of proliferative vitreoretinopathy. Arch Ophthalmol. 2007 Sep;125(9):1161-7.